Management of Chronic Anal Fissure With A Novel Topical Hemp-Herbal Based Ointment - A Pilot Study 

Edward Ram, Zager Yaniv, Raanan Meyer, Dan Carter, Samia Joubran, Nir Hores

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Ninety-two patients were included in the study, 54 (58.7%) were females with a median age of 39 (range 17–78). 32 patients (34.7%) suffered from recurrent AF before enrolling in the study, and 5 patients (5.4%) underwent previous surgical interventions for AF. Three patients (3.2%) were lost to follow-up, leaving 89 patients for analysis. Eighty patients (89.9%) reported significant improvement of symptoms after 1 week using ProctoFiz, and 79 patients reported continued improvement after 1 month of treatment. The mean pain Visual Analog Score (VAS) declined by 6.6 points (8.9 vs. 2.3; 95% CI: 7.20 to −5.99, p < 0.0001) following 1 week of treatment, with continuous improvement to a mean of 0.64 after 1 month. Negative impact on quality of life significantly decreased from a mean of 8.8 to 0.38 following a month of treatment (p < 0.0001), with significant reduction in the number of patients suffering from bleeding following bowel movements (64.1–2.5%; p = 0.0001). 

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​The positive results in this study were achieved using ProctoFiz as the therapeutic agent in conjunction with standard directives regarding stool softeners and dietary advice. We believe that the multi-functional composition of this product effectively addressed the underlying causes of anal fissure